THE IN VITRO ANTIFUNGAL AND SYNERGISTIC ACTIVITY OF SELECTED PLANT EXTRACTS AND ESSENTIAL OILS AGAINST CANDIDA SPP.

This study aimed to evaluate the antifungal activity and potential synergistic of ten plant extracts (EXs) essential oils (EOs) obtained from same species, namely Agrimonia eupatoria L., Arctium lappa Arnica montana Bidens cernua Corylus avellana Echinacea purpurea L. (Moench), Menta piperita Trifolium pratense Syzygium aromaticum Angelica sinensis (Oliv.) Diels were used. Three species genus Candida, C. albicans, glabrata, tropicalis, isolated polluted estuarine water, used in this study. The chemical composition all EOs was evaluated by gas chromatography coupled with mass spectrometry (GC–MS) flame ionization detector (GC–FID) analysis. Firstly, susceptibility Candida spp. strains EXs screened agar disc diffusion method. Then minimum inhibitory concentration (MIC) tested determined a range 256 0.125 µL/mL. Following that, effective divided into two groups (strong effect weak effect) combination + weak) at various concentrations depending on strain determine their using chessboard pattern. most sensitive treatments alone mixtures albicans. potent combinations other EXs/EOs observed for both extract oil, respectively. In much more than when acting growth separately. So, can lead reduction doses commercial antifungals provide an way reduce infections caused yeasts Candida.